Leydig’s Cells vs. Sertoli Cells

Cells that are located along the seminiferous tubules in the testicles that aid with the production of testosterone with the help of luteinizing hormone has the name of Leydig Cells. Whereas, cells that are found in the tubules of the testicles that have the role of developing the spermatids around the testis have the name of Sertoli Cells.

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Leydig Cells vs. Sertoli Cells

Contents: Difference between Leydig’s Cells and Sertoli Cells

Comparison Chart

Basis of DistinctionLeydig CellsSertoli Cells
DefinitionCells that are located along the seminiferous tubules in the testicles that aid with the production of testosterone with the help of luteinizing hormone.Cells that are found in the tubules of the testicles that have the role of developing the spermatids around the testis.
FormationOnly start to prolificate once the 7th week starts during the time of the second trimester.Only prolificate after the completion of one year and therefore become an equal to the follicular cells that exist within women.
LocationLocation within the seminiferous tubules and therefore easy to locate.Location between the germinal epithelial cells that exists along with the seminiferous tubules and therefore harder to locate.
StructureSmall groups and circular shape.No groups and elongated shape.
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What are Leydig Cells?

Cells that are located along the seminiferous tubules in the testicles that aid with the production of testosterone with the help of luteinizing hormone has the name of Leydig Cells. The mammalian Leydig cell is a polyhedral epithelioid cell with a solitary capriciously found the void core. The center contains one to three prominent nucleoli and a lot of dull recoloring fringe heterochromatin. The acidophilic cytoplasm contains various film bound lipid beads and a lot of smooth endoplasmic reticulum. Other than the undeniable plenitude of SER with scattered patches of the harsh endoplasmic reticulum, a few mitochondria are additionally conspicuous inside the cytoplasm. Often, lipofuscin shade and bar molded precious stone like structures 3 to 20 micrometers in breadth are found. They discharge testosterone, androstenedione, and dehydroepiandrosterone (DHEA) when fortified by the pituitary hormone luteinizing hormone (LH). LH expands cholesterol desmolase action (a compound related to the transformation of cholesterol to pregnenolone), prompting testosterone union and discharge by Leydig cells. In guys, the interstitial cells of Leydig, situated in the connective tissue encompassing the sperm-delivering tubules of the testicles, oversee the generation and emission of testosterone. The interstitial cells (Leydig) likely have their cause in the mesonephros and create outside the testicular line in the testicles. From the seventh week, they discharge expanding measures of testosterone. Illustrations include an Interstitial cell of Cajal (ICC) Leydig cells; cells exhibit in the male testicles in charge of the generation of androgen.

What are Sertoli Cells?

Cells that are found in the tubules of the testicles that have the role of developing the spermatids around the testis have the name of Sertoli Cells. The employment of Sertoli cells is to “medical caretaker” creating sperm through this procedure. Situated in the dividers of the seminiferous tubules, they are one of only a handful couple of cells that stay inside the tubules for all time. Since its theoretical capacity is to feed the creating sperm cells through the phases of spermatogenesis, the Sertoli cell has likewise known as the “mother” or “medical caretaker” cell. Sertoli cells additionally go about as phagocytes, devouring the leftover cytoplasm amid spermatogenesis. Translocation of germ cells from the base to the lumen of the seminiferous tubules happens by conformational changes in the sidelong edges of the Sertoli cells. To begin with, Sertoli cells make various substances that start and control sperm generation. Likely the most critical are particles called inhibin and activin, proteins that regulate the activities of FSH (follicle animating hormone). Activin “initiates” FSH generation, while inhibin “represses” it. Made in the pituitary organ, FSH’s capacity in guys is to fortify the central division of sperm cells. The impending intersections of Sertoli cells frame the blood-testis boundary, a structure that parcels the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. The cell is additionally in charge of setting up and keeping up the spermatogonial immature microorganism specialty, which guarantees the restoration of undeveloped cells and the separation of spermatogonia into developing germ cells that advance stepwise through the lengthy procedure of spermatogenesis, completion in the arrival of spermatozoa in a method known as spermiation.

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Key Differences between Leydig’s Cells and Sertoli Cells

  1. Cells that are located along the seminiferous tubules in the testicles that aid with the production of testosterone with the help of luteinizing hormone has the name of Leydig Cells. Whereas, cells that are found in the tubules of the testicles that have the role of developing the spermatids around the testis have the name of Sertoli Cells.
  2. The Sertoli cells only prolificate after the completion of one year and therefore become an equal to the follicular cells that exist within women. On the other hand, the Leydig cells only start to prolificate once the 7th week starts during the time of the second trimester.
  3. The location of both these cells makes for an interesting comparison. The Leydig cells have their location within the seminiferous tubules and therefore easy to locate. On the other hand, Sertoli cells have their location between the germinal epithelial cells that exists along with the seminiferous tubules and therefore harder to find.
  4. The Leydig cells have mostly small groups formed and therefore found within a shorter distance of each other and have a circular or oval shape. On the other hand, the Sertoli cells have elongated nature and do not have enclosing bodies, therefore, exist on their own.
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